1. In a patient with malignant melanoma, what do the following increasing values of thymidine kinase

1. In a patient with malignant melanoma, what do the following increasing values of thymidine kinase (mitotic index _ 2) Breslow _ 3; Clark _ 4 predict? 2. What prognosis can be expected when a malignant melanoma is diagnosed with the results of Clark 4 and Breslow 3? 3. I have been wondering about the colouring of the skin in patients with haemochromatosis. You write ‘bronze skin pigmentation (due to melanin deposition)’, but I can’t understand where the increased melanin comes from? An increased production of melanin-stimulating hormone (MSH) doesn’t seem to fit in well with the decreased function of the gland regarding other hormones.

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