1. Obese patients have a resistance to the action of insulin due to which hyperinsulinemia is…

1. Obese patients have a resistance to the action of insulin due to which hyperinsulinemia is present in the early stages of type 2 diabetes. Identify the FALSE statement of mechanism of insulin resistance in T2DM. A. Accumulation of metabolites involved in fatty acid esterification causing an inhibition of insulin signaling. B. Increased TNF-a levels. C. Downregulation of glucose transporter (GLUT)-1 receptors. D. Production of reactive oxygen species (ROS) contributes to insulin resistance.

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