1. What is the recommended upper limit dose of lamotrigine when combined with both carbamazepine and

1. What is the recommended upper limit dose of lamotrigine when combined with both carbamazepine and valproate? 2. Is a valproate–lamotrigine combination more effective than carbamazepine on its own against partial seizures? 3. Why is the incidence of parkinsonism less common in smokers? 4. Is it recommended to start the treatment of parkinsonism with dopamine agonists alone in elderly (over 60 years old) patients, and to delay using L-dopa until the disease has progressed much further? Is there a rationale for this protocol in younger patients?

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