A 24-year-old wom an com plained to her physician that she had to go to the bathroom several tim es.

A 24-year-old wom an com plained to her physician that she had to go to the bathroom several tim es at night. Two weeks earlier, the wom an had started a treatm ent w ith spironolactone for excessive hair on her face and arm s. Which of the follow ing m olecular actions m ost likely m ediated the patient’s nocturia? A. Com petitive blockade of a1 receptors of the bladder internal sphincter B. Activation of M3 receptors on the detrusor m uscle C. Osm otic action on the thin descending loop of Henle D. Com petitive blockade of aldosterone receptors E. Blockade of Na+/Cl- sym port in the early distal tubule

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