A 32-year-old African Am erican m an w ho worked as a Peace Corps volunteer in Ghana presented w ith

A 32-year-old African Am erican m an w ho worked as a Peace Corps volunteer in Ghana presented w ith weakness, fatigue, yellow ing of his skin and sclera, and slight fever. He recently was given chloroquine as a prophylaxis for m alaria. Laboratory ndings con rm ed the diagnosis of hem olytic anem ia likely due to chloroquine treatm ent. This patient’s disease was m ost likely m ediated by genetic polym orphism of w hich of the follow ing enzym es? A. N-acetyltransferase B. Glucose-6-phosphate dehydrogenase C. Reduced form of nicotinam ide adenine dinucleotide (NADH)-m ethem oglobin reductase D. Pseudocholinesterase E. Glucuronosyltransferase

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