A 48-year-old wom an w ho had been su ering from breast cancer for 2 years was adm itted to the…

A 48-year-old wom an w ho had been su ering from breast cancer for 2 years was adm itted to the hospital w ith a diagnosis of deep venous throm bosis. An intravenous (IV) loading dose of heparin was adm inistered, followed by an IV infusion. After 6 hours of heparin therapy, the patient’s activated partial throm boplastin tim e (aPTT) had not increased relative to her heparin pretreatm ent levels. W hich of the follow ing statem ents best explains this nding? A. The patient had high plasm a levels of heparin-binding proteins. B. The patient’s therapy included a vitam in K supplem ent. C. Heparin has a very short half-life (2 to 4 m inutes). D. Heparin e ects are delayed at least 12 hours after administration. E. The patient had high plasm a levels of antithrom bin III.

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