A 52-year-old m an w ith Addison disease presented to the hospital complaining of episodic weakness,

A 52-year-old m an w ith Addison disease presented to the hospital complaining of episodic weakness, paresthesias, and constipation. He had been taking cortisol and udrocortisone for several m onths. On adm ission, his blood pressure was 160/98 m m Hg, and an electrocardiogram showed prolongation of the Q-T interval. Lab results revealed a K+ serum level of 2.5 m Eq/L (norm al 3.5-5.0 m Eq/L). Which of the follow ing events best explains the patient’s syndrom e? A. Cortisol-induced hyperglycem ia B. Fludrocortisone excess C. Inadequate therapy of adrenal insu ciency D. Cortisol-induced myopathy E. Essential hypertension

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