A 52-year-old wom an com plained to her physician of a persistent gastric pain every tim e she took.

A 52-year-old wom an com plained to her physician of a persistent gastric pain every tim e she took a prescribed drug. The wom an, recently diagnosed w ith severe osteoporosis, had started a therapy w ith oral alendronate 1 week earlier. The physician suspended alendronate and prescribed intravenous adm inistration of zoledronate, explaining to the patient that a single injection would be e ective for at least 5 to 6 m onths. Zoledronate has a half-life of about 7 days. Which of the follow ing best explains the reason for the exceptionally long e cacy of the drug? A. Alteration of gene expression of bone osteoblasts B. Incorporation into bone hydroxyapatite crystals C. Repeated enterohepatic cycling of the drug D. Very slow biotransform ation to active interm ediates E. Irreversible binding to plasm a proteins

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