A 54-year-old m an su ering from fam ilial hypercholesterolem ia started treatm ent w ith lovastatin

A 54-year-old m an su ering from fam ilial hypercholesterolem ia started treatm ent w ith lovastatin and cholestyram ine. W hich of the follow ing actions m ost likely m ediated the therapeutic e ect of both drugs in the patient’s disease? A. Decreased intestinal reabsorption of bile acids B. Decreased conversion of cholesterol to bile acids C. Decreased synthesis of cholesterol by the liver D. Upregulation of hepatic low -density lipoprotein (LDL) receptors E. Decreased synthesis of triglycerides by the liver

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