A 64-year-old wom an com plained to her physician of persistent back pain for the past 3 days….

A 64-year-old wom an com plained to her physician of persistent back pain for the past 3 days. Dual-energy x-ray absorptiom etry showed di use osteoporosis of the spine and hips. The physician prescribed calcium and vitam in D sup – plem entation and alendronate, one tablet daily. W hich of the follow ing actions m ost likely m ediated the therapeutic e ect of alendronate in the patient’s disease? A. Stim ulation of osteoblast activity B. Stim ulation of intestinal calcium absorption C. Inhibition of renal calcium excretion D. Inhibition of osteoclast activity E. Inhibition of renal synthesis of calcitriol

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