A 66-year-old m an su ering from t ype 2 diabetes had been receiving a com bination therapy w ith m.

A 66-year-old m an su ering from t ype 2 diabetes had been receiving a com bination therapy w ith m etform in and glyburide, but 2 m onths later lab exam s indicated that the control of his diabetes was inadequate. His physician decided to add pioglitazone to the treatm ent regim en. Which of the follow – ing m olecular actions m ost likely m ediated the therapeutic e ect of the added drug in the patient’s disease? A. Slow ing glucose absorption from the gastrointestinal tract B. Blockade of K+ channels in pancreatic ß-cell m em branes C. Inhibition of incretin horm one m etabolism D. Activation of glucagon-like polypeptide-1 (GLP-1) receptors E. Activation of adenosine m onophosphate (AMP)-activated protein kinase F. Regulation of transcription of genes related to glucose utilization

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