A 67-year-old m an su ering from term inal cancer started analgesic treatm ent w ith an opioid drug.

A 67-year-old m an su ering from term inal cancer started analgesic treatm ent w ith an opioid drug. Know ing that tolerance to opioids is pronounced, w hich of the follow ing drug param eters was m ost likely increased after a few days of treatment? A. Maxim al e cacy B. Median e ective dose C. Therapeutic index D. Potency E. Half-life

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