A 74-year-old m an com plained to his physician of m em ory im pairm ent that had worsened over the.

A 74-year-old m an com plained to his physician of m em ory im pairm ent that had worsened over the past 2 m onths. He also reported that he had increasing di culty in recognizing fam iliar objects and in planning everyday activities such as shopping. Physical exam ination revealed no neurologic de cits, but the m an perform ed very poorly in the Folstein Mini-Mental Status Exam . Donepezil was prescribed. Which of the follow ing m olecular m echanism s m ost likely m ediated the therapeutic e ect of the drug in the patient’s disease? a. Inhibition of norepinephrine reuptake b. Stim ulation of norepinephrine release c. Blockade of nicotinic neuronal receptors d. Inhibition of cholinesterase e. Blockade of m uscarinic M1 receptors f. Inhibition of choline acetyltransferase

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