A clinical trial w as conducted by orally adm inistering a new analgesic drug to a group of patients

A clinical trial w as conducted by orally adm inistering a new analgesic drug to a group of patients su ering from arthritic pain. One hour after adm inistration, the patients were questioned about pain relief, and a sam ple of blood was collected from each patient to m easure plasm a drug levels. Pain relief generally correlated well w ith plasm a levels, but three patients whose plasm a levels were equal to zero reported good pain relief. Which of the follow ing is the m ost likely explanation of the analgesic e ect of the drug in those three patients? A. High bioavailability of the drug B. Sm all volum e of distribution of the drug C. Very low clearance of the drug D. Poor patient com pliance E. Placebo effect

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