A patient with alpha1-antitrypsin deficiency has repeat PFTs, including a diffusing capacity of the.

A patient with alpha1-antitrypsin deficiency has repeat
PFTs, including a diffusing capacity of the lung for carbon monoxide (DLCO).
Based on a computer-assisted interpretation, there appears to be a remarkable
decrease in the percent-of-predicted value for DLCO. It was previously normal;
now it is 68% of predicted, indicative of emphysema. An effective therapy,
pooled human plasma alpha1-antitrypsin, is available but expensive. What
additional information should the clinician evaluate?

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