Currently favoured regimens for eradication of Helicobacter pylori are triple therapy with a proton.

Currently favoured regimens for eradication of Helicobacter pylori are triple therapy with a proton pump inhibitor along with two antibiotics for 1 week. For example: ? Omeprazole 20mg _ metronidazole 400 mg and clarithromycin 500 mg (all twice daily). ? Omeprazole 20mg _ clarithromycin 500 mg and amoxicillin 1 g (all twice daily). Resistance to amoxicillin has not yet been demonstrated. Previously, regimens such as omeprazole, metronidazole, amoxicillin and clarithromycin were recommended; are these regimens no longer used? The reason behind this question is the ‘sky-high’ cost of clarithromycin in Pakistan, which is inversely proportional to patient compliance (that is, low-cost regimens tend to have a higher rate of compliance).

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