Major components to cell motility are directed motion, chemotaxis, and random motility….

Major components to cell motility are directed motion, chemotaxis, and random motility. Since cells normally migrate at speeds on the order of gm per minute, the effective distance a cell can migrate is limited especially if its motility is dominated by random motion. The relative effects of chemotaxis and random motility then become important in determining the range in cell motility. This can be accomplished by formulating time constants for each process and comparing them by a dimensionless ratio.The chemotactic velocity is given by:where 4) = orientation bias and S = cell speed. 0 is a parameter that measures the degree of directional bias for different cell types, and it ranges from 0 for completely unbiased movement to unity for completely biased movement. Typical values for 0 are as follows:V, = 0S,

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