Methacholine is a drug used to induce airway constriction in patients suspected of having. In…

Methacholine is a drug used to induce airway constriction in
patients suspected of having. In healthy subjects, only higher doses of
methacholine cause bronchospasm. In asthmatics, very low doses can precipitate
a 20% decrease in the forced expiratory volume in 1 second (FEV1). The
methacholine challenge test begins with a low dose and increases the
concentration (either doubling or quadrupling) until the patient has a
significant change in FEV1 or the highest dose has been given. Methacholine is
supplied in vials that contain 100 mg of the active substance to which 6.25 ml
of diluent (saline) can be added to produce a concentration of 16 mg/ml. This
is the highest dosage administered to the patient. How can you make serial
dilutions of the drug so that five different dosages are available and each one
is four times more concentrated than the previous dose?

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